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Interestingly, a specific GPX1 polymorphism resulting in a proline-to-leucine transition at position 198 (Pro198Leu) is associated with a reduction in GPx1 activity and found to be more prevalent in Keshan patients

Samples were loaded onto a Superose 6 10/300 GL column (GE HealthCare) pre-equilibrated with phosphate-buffered saline (PBS) containing 0.15 M NaCl and 0.02% sodium azide

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For those with blood disorders like thrombocytopenia (low platelet count) or von Willebrand disease , bruising risks are significantly higher