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University of Pittsburgh Medical Center

The pooled RR for fractures in patients treated with GLP-1RAs compared with those treated with placebo or other anti-diabetic drugs was 0.77 (95 % CI: 0.61-0.96)

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Diabetes drug tirzepatide has been shown to help people lose almost 16% of their body weight in a clinical trial, and it could soon join semaglutide and liraglutide in the ranks of buzzy weight loss medications on the market

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Using both is generally considered safe, and the combination might theoretically be synergistic for migraine prevention, with CGRP inhibitors blocking the receptor directly while tirzepatide reduces CGRP production upstream