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One study showed that changing to every other day dosing of tamsulosin resolved ejaculatory symptoms in 63% of patients without an appreciable worsening of urinary symptoms

The mechanism underlying this association likely relates primarily to rapid weight loss rather than direct drug toxicity

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Interestingly, an adjacent population of GABAergic neurons is activated by fasting but inhibited by the proopiomelanocortin (POMC) cleavage product alpha-melanocyte stimulating hormone (alpha-MSH), and their activation increases food intake [108]