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ExcelMale forum members who have tracked labs while using GHK-Cu (both topical and injectable) have consistently reported no measurable change in serum DHT or estradiol

10.1523/JNEUROSCI.4336-03.2004 J

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This tachyphylaxis of gastric emptying is best documented for long-acting GLP-1 receptor agonists, where short-acting agents produce large, sustained emptying delays while long-acting agents produce an emptying delay that wanes with continued dosing

Some research protocols have explored doses up to 4.5 mg weekly, which showed slightly greater efficacy in the phase 2 dose-finding trial but also increased side effect burden