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Furthermore, many researchers have found that reduced GSH levels and GSH-dependent antioxidant enzyme activity in damaged myocardium due to excess ROS and disruption of the GSH synthesis process, along with increased oxidative damage and ferroptosis

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If the root cause happens to be something serious, a supplement may interact poorly with or mask the problem and lead to further complications down the line

Funding This study was supported by grants from the National Natural Science Foundation of China (82302925, 82272702), Natural Science Foundation of Zhejiang Province (LQ23H160012, LZ23H160001, LTGY23H080005), the project of Science and Technology Plan of Traditional Chinese Medicine of Zhejiang Province (2024ZL1010), Wenzhou Science and Technology Bureau of China (ZY2023021), and in part supported by the Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A)

Furthermore, GSTP1-1 has also been shown to bind and inhibit tumor necrosis factor receptor-associated factor 2 (TRAF2), an upstream activator of JNK, thus blocking the MAPK/JNK signaling cascade at multiple levels 29

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