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In clinical trials, tirzepatide produced greater weight loss than semaglutide at comparable timepoints, suggesting more potent metabolic effects overall

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Gaillard PJ, Appeldoorn CC, Dorland R, van Kregten J, Manca F, Vugts DJ, Windhorst B, van Dongen GA, de Vries HE, Maussang D, et al

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This process acts as a sink for free cysteine and can lead to metabolic vulnerabilities and toxicity in NRF2-activated tumours

Dosage often depends on the delivery method and what youre hoping to achieve