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Inflammatory cytokines and testicular microenvironment Hyperglycemia-induced oxidative stress activates inflammatory pathways, increasing pro-inflammatory cytokines, such as tumor necrosis factor- (TNF-) and interleukin-1 (IL-1), in diabetic patients [40]

Liver disease can also induce changes in the gut microbiome (Fouts et al

Nishibori, N., Fujihara, S

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Indeed, the last three rows of Table 5 show that the up-regulation of CBS has exactly this effect and that the addition of oxidative stress makes the effect much stronger