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Endothelial cell and T-cell crosstalk: targeting metabolism as a therapeutic approach in chronic inflammation

Topical application results in much lower systemic absorption, significantly reducing these risks

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The structural designs of all pipeline antagonists are schematically illustrated in Fig

Alternative approaches include supplementing with precursor nutrients such as N-acetylcysteine (NAC), which the body can use to synthesise glutathione naturally, though NAC is also not recommended for NAFLD in NICE guidance and should not be self-prescribed for liver disease