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Thus GLP-1 was shown to regulate a number of diverse functions: reduction in digestive enzyme secretion, slowing of gastric motility, increases in heart rate and blood flow, increased bone remodeling, and suppression of appetite (via hypothalamic and brainstem nuclei)

Whereas some of the previous diabetes medications caused indiscriminate release of insulin, which lowered blood sugar levels but caused many people to gain weight by sending hunger out of control, the GLP-1 agonists only allow for so much insulin to be released after a meal

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The SURPASS and SURMOUNT trial programs Tirzepatide was evaluated in over 10,000 participants across the SURPASS (type 2 diabetes) and SURMOUNT (obesity) trial programs

A diet high in carbohydrates increases circulating levels of insulin, which promotes fat storage, increased hunger, and cravings