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In summary, FOXO4 plays a critical role in multiple diseases, and studies have shown that endothelial cell senescence accompanies these conditions

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Despite the promising findings reported in preclinical studies, it is important to emphasize that the majority of the available evidence originates from animal models and cell culture experiments

Intestinal permeability, or leaky gut, is a common trigger in autoimmunity, allowing undigested food particles and toxins to enter the bloodstream, which provokes an immune response and fuels inflammation