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Materials and methods Animal selection and care In the current study, forty adult male albino rats ( Rattus norvegicus ) were obtained from the National Research Centre, Giza, Egypt

The active metabolites of Pycnogenol, particularly the smaller phenolic acids and the gut-derived metabolite M1, can enter the central nervous system

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The report noted no adverse biochemical changes, but an uncontrolled open-label design with no comparator cannot establish a safety profile [4]

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