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Furthermore, a RCT documented the anti-inflammatory effects of moega-3 supplementation in patients with migraine (138)

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On one hand, pro-inflammatory immune cells (e.g., M1-type macrophages, Th17 cells) directly or indirectly contribute to cartilage degeneration and extracellular matrix degradation by releasing inflammatory factors (e.g., TNF-, IL-1, IL-6) and matrix-degrading enzymes (e.g., MMPs, ADAMTS)

Biofactors 45:930943