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Both GLP-1R and GIPR belong to the class B GPCR family and signal primarily through the GscAMP pathway to promote glucose-dependent insulin secretion from pancreatic -cells

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Decreasing preference for high-caloric, high-fat foods is a powerful action of GLP-1RA and dual GIPR/GLP-1R agonist therapeutics, which may contribute to the weight loss success of these drugs

The commonly referenced therapeutic range of 0.25-0.5 mg daily (250-500 mcg) extrapolates from the effective rat dose of approximately 10 mcg/kg body weight