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Troyano A, Sancho P, Fernandez C, de Blas E, Bernardi P, Aller P

Metabolism, mitochondrial dysfunction, and redox homeostasis in pulmonary hypertension

Recently, ferroptosis, a distinct form of regulated cell death driven by iron overload and lipid peroxidation, has emerged as a novel mechanism potentially involved in RM

CPLA2 triggers PGE 2 biosynthesis through COX-1 and can induce expression of Il10, Ptgs2 , and Nr4a2 , while suppressing Tnf expression in MAPK by increasing cAMP (Yun et al., 2016)

Remarkably, the combination therapy efficiently activates the AMPK pathway while suppressing the mTOR pathway