Based on Phase 2 trial data, retatrutide's side effect profile appears broadly consistent with other incretin-based therapies, though the addition of glucagon receptor agonism introduces some distinct considerations
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11 Causality has not been established, and absolute event rates are low, but the practical implications are straightforward
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RANTES, a pro-inflammatory chemokine, was demonstrated to reduce glucose-dependent secretion of GLP-1 and GLP-2, thereby impairing glucose-induced insulin secretion in mice (112)
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