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They conducted the Study of Tirzepatide Compared with Dulaglutide on Major Cardiovascular Events in Participants with Type 2 Diabetes (SURPASS-CVOT) to settle a couple of questions, explains Nicholls: Given that there is a lot of interest in developing new incretin therapies, can we achieve better outcomes (metabolic or clinical) with combination therapy, and can we develop agents that are better tolerated

Rolling creates a gentle swirling motion that encourages dissolution without the mechanical force that can break peptide bonds

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Pancreatitis is a known, rare risk with GLP-1s

The research also included qualitative assessments of data from case reports, case series, pharmacovigilance analyses, and other studies unsuitable for quantitative pooling

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