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And while it may increase GLP-1 secretion in the gut, studies have found that it may also limit insulin production which may not be good for blood sugar levels

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel non-bile acid FXR agonist tropifexor (LJN452) in healthy volunteers

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Am J Physiol Regul Integr Comp Physiol 283 : R905R910

Weight Loss Outcomes (48 weeks): 1 mg: 8.7% 4 mg: 17.1% 8 mg: 22.8% 12 mg: 24.2% Side Effects : Gastrointestinal issues (nausea, vomiting), cardiovascular monitoring advised