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The agency's position, restated in its public guidance, is that "retatrutide and cagrilintide cannot be used in compounding under federal law" because they are investigational compounds not eligible under sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act [6][14][15]

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They can inhibit adipogenesis by regulating key signaling pathways and transcription factors such as PPAR and C/EBP, thereby limiting the formation and differentiation of new adipocytes (497)

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