Topical application must penetrate the skin barrier, and even the best formulations lose a significant portion of the active compound during that process
For practical purposes, this distinction matters less than you might think
Subcutaneous injection near injury sites may provide localized benefit, though BPC-157 also migrates systemically to damaged tissues from any injection location
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And regardless of the t1/2 of GSH the triggers are sufficient to cause this type reaction for hours to days
It remains in the injected area and may add temporary volume , but this is localized and not reflective of systemic weight gain