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Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by activating NF-kappa B via Ref-1

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A phase I/II trial evaluating YL201 in patients with advanced solid tumors including mCRPC (NCT06057922), as well as a phase II trial in patients with mCRPC (NCT06241846), are both currently recruiting subjects 100,102

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IGF-1 crosses the blood-brain barrier and supports hippocampal neurogenesis, synaptic plasticity, and neuronal survival