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(ii) comprehensive pharmacokinetic, biodistribution, and long-term toxicology profiles validated in large-animal models (e.g., canine osteosarcoma, which closely mimics human disease)

Trends in Endocrinology and Metabolism

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All the kids have been sick and my Immune system is up

Popp 1984) and classification of preneoplastic and neoplastic lesions of the rat and mouse liver in book chapters (Bannasch and Zerban 1990