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Importantly, in the same paper the anti-obesity efficacy experiment in diet-induced obese mice was carried out by systemic administration of the inhibitor the researchers did not report an oral-gavage efficacy arm
[6] The investigators concluded that the lipolytic actions were not explained by direct beta-3-receptor activation, although increased receptor expression could contribute to enhanced lipolytic sensitivity after longer exposure
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V., Zavarzina, N
AOD-9604 does not negatively affect insulin sensitivity
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