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This triple receptor activity is the defining mechanistic feature that distinguishes Retatrutide from related compounds: Semaglutide acts on GLP-1R alone, while Tirzepatide targets GLP-1R and GIPR without glucagon receptor involvement

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However, given the associated risks of cardiovascular disease and various cancers, the benefits of these medications, such as better glycemic control, weight loss and improvement in cardiometabolic risk factors as well as other obesity complications, appear to outweigh the risks for most adults with obesity [143, 153]