surmount-1 trial tirzepatide weight loss non-diabetic 🤔Adults with type 2 diabetes and obesity lose less on EVERY GLP-1 drug compared to those without diabetes, consistently ~5% less. Now that we have retatrutide's TRIUMPH-2 data today we can REDEFINE 4 vs SURMOUNT: how

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Also, the effectiveness of Vitamin B12 is further amplified when combined with folic acid and controlled sun exposure

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Future studies expanding patient-derived brain organoids and PBMC analyses to capture genetic, immunological, and disease-stage heterogeneity, particularly during acute disease, would further improve the translational relevance and guide precision clinical trials