Reward Pathways: GLP-1 RAs modulate the mesolimbic reward system (including the ventral tegmental area and nucleus accumbens), potentially reducing the hedonic drive to consume palatable foods and even moderating addictive behaviors (Zheng et al., 2024)
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Lifestyle change remains the foundation for all weight loss GLP-1 agonists like Wegovy, Saxenda, and Zepbound are designed to be used for the chronic treatment of obesity, not something to be used in the short-term