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Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

What Are the First Signs of B12 Deficiency

[9] With the standard regimen, we do not expect any liver issues or nerve issues

Considerations for Patients with Malabsorption Disorders Those with malabsorption issues, like celiac disease or Crohns disease, might need more B12

After approximately 2 to 3 days of hospitalization, the patient returns to his or her daily activities and may resume driving in 1 week

While theres no universally best time, some patients prefer morning injections to take advantage of the energy-boosting effects throughout the day