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Within this framework, addiction may reflect dysregulation of an ancient energy-reward axis, whereas Parkinsons disease may reflect failure of a primordial dopamine-centered mitochondrial program affecting both motor and cognitive function

More practical contributors to heart rate increases, especially early in therapy, may include volume depletion from gastrointestinal side effects such as nausea, vomiting, and diarrhea, which are common during GLP-1 receptor agonist initiation

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