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Stress pathways induced by these factors, including endoplasmic reticulum stress, oxidative stress, mitochondrial dysfunction, and autophagy, are all involved in the induction of -cell apoptosis, and these pathways may occur simultaneously at the same level or may interact to further exacerbate -cell death in the form of superimposed harmful stress
All authors contributed to interpretation of the data
Beyond these, the pipeline includes additional oral small molecules, once-monthly injectables, and further multi-agonist combinations
The presence of fluorescent label in the DMNX was accepted as a marker of incomplete vagotomy
Proteins linked to Rho signaling and calpain-regulated actin dynamics, such as Rho GTPase-activating protein 17, and Four and a half LIM domains protein 2 (FHL2) were decreased
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