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Its binding to VMAT2 is very strong, making it's effect appear irreversible, with trace amounts of the drug remaining bound to vesicular membranes for many days, and its clinical effects lasting many days to weeks, and may persist until new transporter proteins are synthesized (German et al, 2015
therefore, it did not receive as much fanfare as the latter two
Currently running 8-week cycles with 4-week breaks
That asymmetry may be the single most important clinical implication of this study.Using the drug for 0.5, 1, or even 1.5 years and then stopping produced no significant cardiovascular benefit at 3 years
the ligand activates its GPCR, which in turn activates intracellular G proteins
No lethal dose was reached in preclinical toxicology studies, and no significant adverse effects have been reported in published research
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