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Since THC is a partial CB1R agonist, a concern could be that it might inhibit GLP-1 release and attenuate the effects of semaglutide

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PMID: 139 Flores-GuerreroJLOstMCJKienekerLMGruppenEGWolak-DinsmoreJOtvosJDet al

GLP-1 receptor agonists, such as semaglutide and liraglutide, are increasingly prescribed for type 2 diabetes and weight management in the UK

Obesity management for the treatment of type 2 diabetes: standards of medical care in diabetes-2020

Increased cellular protein S -glutathionylation sensitized hepatocytes to TNF hepatotoxicity Increased cellular glutathionylated protein levels in response to GSSG accumulation prompted us to examine the effects of cellular protein S -glutathionylation on TNF-induced cell death