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Human GIP(3-30)NH 2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors
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Key Ingredients Water, Butylene Glycol, Caprylic/Capric Triglyceride, Glycerin, Cetyl Ethylhexanoate, Propanediol, Pentaerythrityl Tetraisostearate, Niacinamide, 1,2-Hexanediol, Polyglyceryl-10 Laurate, Vinyl Dimethicone, Hydrogenated Lecithin, Saccharide Hydrolysate, Ethylhexylglycerin, Adenosine, Niacinamide, Bakuchiol, 3-O-Ethyl Ascorbic Acid, Houttuynia Cordata Extract, Glutathione (5 ppm), Myosotis Sylvatica Flower/Leaf/Stem Extract, Oenothera Biennis (Evening Primrose) Flower Extract
Dual Hormonal Action: In addition to mimicking the effects of GLP-1 , Tirzepatide also activates GIP , a hormone that enhances insulin secretion and increases energy expenditure
Interestingly, compared with the basal-bolus insulin regimen, the combination of GLP-1RA and basal insulin displayed a similar benefit in lowering HbA1c with a 33% lower risk of hypoglycemia and 5.66 kg less body weight gain (21)
