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However, the slower tirzepatide titration may improve tolerability by allowing more gradual adaptation

Its not uncommon in medicine to encounter situations where a treatment, especially one addressing a longstanding deficiency, might initially seem to exacerbate symptoms

If youre not fine with it, hormone replacement therapy exists for a reason, and that reason is it makes you feel way better, he said on his podcast

So it also depends on how active you are

This can result in rapid-onset hyperkalemia, malignant arrhythmias, and sudden cardiac arrest , sometimes in children with previously undiagnosed muscular dystrophy (Bohringer et al., 2019

the study physician attributed the death to pre-existing coronary artery disease unrelated to the drug, but the FDA's Pharmacy Compounding Advisory Committee cited this "unresolved cardiac signal" in December 2024 as a reason to keep the compound off the approved compounding list