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At 1 mg its occupancy sits near 1%, and liver fat still fell 51% over 48 weeks in the trial participants who started with fatty liver. Natural glucagon reaches a similar 0.5 to 5% engagement during a fast, so 1% is not an unusually small signal

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Activated sulfonamides are cleaved by glutathione-S-transferases [PMID: 10460796] Laboratory literature summary: Activated sulfonamides are cleaved by glutathione-S-transferases