Providers take additional precautions for individuals with gallbladder disease, diabetic retinopathy, or a history of hypersensitivity reactions (47)
Millions more are likely to join them with Medicares coverage broadening under the Bridge program
It signals fullness to the brain, slows gastric emptying, stimulates glucose-dependent insulin release, and over time produces significant weight loss for most patients
The new microdosing strategies could bolster business models, but long-term viability depends on the current FDA compounding rules
Last reviewed: July 1, 2026 Last updated: July 1, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Affected individuals are typically characterised by lipoatrophic diabetes, insulin resistance and hepatic steatosis ( Agonists of the glucagon-like peptide-1 receptor (GLP-1R) deliver significant beneficial effects both in treating type 2 diabetes and obesity ( Reports of the effects of GLP-1R agonists in individuals with inherited lipodystrophies are currently limited to only 3 case studies, and these examine FPLD but not CGL patients ( Here we used a well validated Bscl2 -null (seipin knockout) mouse model of CGL type 2 (CGL2) to examine the effectiveness of a GLP-1R agonist, in treating lipoatrophic diabetes, hepatic steatosis and hyperphagia in CGL to inform the adoption of this class of drugs for individuals with lipodystrophy