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Non-thymic cells, including macrophages and fibroblasts, were exposed to oxidative stress, heat, apoptosis, or necrosis

Hazneci E, Karabulut AB, Ozturk C, Batcioglu K, Dogan G, Karaca S, et al

Validity of conclusions Although biological plausibility and observational evidence support an association between periodontitis and cardiovascular outcomes, definitive evidence that periodontal treatment reduces hard cardiovascular endpoints such as myocardial infarction, stroke, or cardiovascular mortality is still lacking

doi: 10.1007/s43450-021-00130-z 127

Elevated levels of insulin and insulin-like proteins have been associated with a reduction in lifespan

Cold Spring Harb Perspect Biol 7 , a020412 (2015)