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Upregulation of GSTT1 and GSTP1 might have important consequences for TCC growth by providing a reduced cellular environment and inhibition of apoptotic pathways

10.1111/pai.12661 150

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These enzymes degrade alveolar supporting structures including the structural prote in vitro nectin ( 94) and activate latent TGF- via proteolytic cleavage, converting local immune activation into a persistent pro-fibrotic signal