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Baicalein, a constituent of Baikal skullcap, has alpha-glucosidase inhibitory activity in vitro
The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes
Most supplements contain only around 1-5 g of L-arginine, so it would be difficult to take too much
Although a decrease in systolic blood pressure is observed with GLP-1 RAs (ranging from 1.84 mmHg [95% CI 3.48 to 0.20] to 4.60 mmHg [95% CI 7.18 to 2.03]) [113], the possibility of requiring adjustment of simultaneous diuretic treatment should be considered
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