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Some participants in GLP-1 weight loss programs have experienced more severe side effects, though they are less common

The STEP program enrolled patient populations with a range of comorbid conditions, including those with and without T2D

Once transitioned into a liquid state, the peptide is highly sensitive to thermal breakdown and mechanical stress

N.GanaieF.ImH.et al

These include: These symptoms happen because retatrutide affects gut hormone pathways involved in appetite, digestion and weight regulation

According to the MHRA-approved product information, these include: Nausea (very common, affecting more than 1 in 10 patients) Vomiting and diarrhoea (common, affecting up to 1 in 10 patients) Abdominal pain and constipation (common) Decreased appetite (common) These gastrointestinal symptoms typically occur during the initial weeks of treatment or following dose escalation and often diminish over time as the body adjusts to the medication