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Yes, when taken in the recommended doses, glutathione is safe for long-term use

Nausea peaks on days 1 to 3 and usually improves by day 4 or 5

He L, He T, Farrar S, Ji L, Liu T, Ma X (2017) Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species

Typically, starting GLP-1 medication is a gradual process, with doses slowly increased over 16 to 20 weeks to help your body adjust and to minimize potential side effects