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Zepbound has an FDA-approved indication for moderate-to-severe obstructive sleep apnea in adults with obesity when used with diet and physical activity

Furthermore, the weightloss effect of the product was shown to be sustainable, with no significant body weight rebound in the short term after drug withdrawal, a feature superior to traditional antiobesity medications

However, stopping any GLP-1 after just 12 weeks requires either transitioning to intensive behavioral support or accepting high rebound risk

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Eur J Endocrinol 183(5):R119R132 Yamada C, Yamada Y, Tsukiyama K, Yamada K, Udagawa N, Takahashi N, Tanaka K, Drucker DJ, Seino Y, Inagaki N (2008) The murine glucagon-like peptide-1 receptor is essential for control of bone resorption

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