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Importantly, at study completion, 5A-1MQ-treated mice had a lower fat mass than the obese WD controls and their vehicle-treated counterparts and were not significantly different (with FDR correction) from the LD control mice (Fig

9 The effects of high-protein diets remain controversial

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Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown even greater efficacy in some studies, with weight reductions of approximately 20% in the SURMOUNT-1 trial