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For the HEDS assays, either GSH was varied between 100 M and 1.5 mM for ScGrx (or 250 M and 3.0 mM for PfGrx) at fixed concentrations of HEDS (0.18, 0.37, 0.55 and 0.74 mM) or HEDS was varied between 90 and 920 M at fixed concentrations of GSH (0.3, 0.5, 1 and 1.5 mM for ScGrx7 or 0.25, 0.5, 1 and 2 mM for PfGrx)
Glutathion-S-Transferasen (GST) katalysieren die Konjugation von GSH mit elektrophilen Toxinen, Arzneimitteln und Metaboliten wodurch hydrophile Konjugate entstehen, die leicht ber die Nieren oder die Galle ausgeschieden werden knnen
THE ANTI-CELL DEATH ROLE OF GSH The anti-cell death functions of GSH are mediated through coordinated control of oxidative stress, redox-sensitive signaling, and cysteine-based protein modification, thereby setting the threshold for commitment to regulated cell death
Although this provides substrates for cellular metabolism, it also significantly promotes the abnormal accumulation of ROS
Administer the Injection Hold the syringe like a dart
Mito-TEMPO, a mitochondrion-targeted antioxidant, significantly rescued doxorubicin (DOX)-induced myocardial ferroptosis, substantiated that mitochondrial oxidative damage underlies ferroptosis-induced cardiac injury [57]
