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Between 46% and 75% of people taking Orforglipron (compared to just 9% in the placebo group) lost at least 10% of their body weight
Constipation and diarrhea are also common, though they tend to be mild to moderate and manageable with dietary modifications
Method: Subcutaneous injection (under the skin)
In people with obesity, particularly in cases of rapid or marked weight reduction, the decline in lean mass may account up to 2530% of the total weight loss, contributing to the so-called sarcopenic obesity [18]
In addition, exenatide has been shown to not prolong the QTc interval at supratherapeutic concentrations [9, 10]
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