The triple agonist mechanism addresses weight through both reduced caloric intake and increased energy expenditure
Novick RM, Mitzey AM, Brownfield MS, Elfarra AA (2009) Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes
Chronic use protocols in humans are essentially unstudied
Loose skin, clothes fitting differently, and changes in how other people respond to you all contribute, and talking to a friend, partner, or therapist about these changes can help
However, this same action that helps you lose weight is also the main reason you might be feeling that burn
Cost concerns - Some people feel the price is high compared to other supplements