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Overall, most of those papers are in favor of a possible contribution of polymorphisms in folate-related genes as maternal risk factors for the birth of a child with DS, however, they are often conflicting and limited by the small sample size of case-control cohorts (Table 1)
They havent been proven to have the same therapeutic effects as the approved formulation, raising concerns about effectiveness and potential risks
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n: Control (DMSO) = 26
Therefore, lipid-overloaded macrophages turn into foam cells, which is one of the earliest cellular hallmarks of the atherosclerotic process (Bobryshev, 2006
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