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(2020) noted that GHK-Cu possesses prominent antioxidant and anti-inflammatory effects, and that preliminary observations suggest it can partially reverse cognitive impairment in aging mice by targeting anti-inflammatory and epigenetic pathways

Unlike classic dietary antioxidants (vitamin C, vitamin E) which localize to specific compartments, melatonin being both lipophilic and hydrophilic distributes through all cellular compartments, especially concentrating in mitochondria where the majority of ROS are produced

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Validation with longitudinal studies with a larger population size would further help to develop early screening tools for AD based on the same idea and is under process in our lab

Neurosci Lett 192: 1316