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Primary endpoints: TRAP telomerase activity
To expand the prognostic application, a risk stratification model based on these enzymes was developed using the LASSO Cox regression algorithm
No long-term safety data exists for any of these compounds in humans
In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)
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The study found that 5MQ significantly inhibited HeLa cell proliferation in a concentration- and time-dependent manner
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