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Phase 2 monotherapy (Lau et al., 2021): 706 adults with overweight/obesity across 57 sites

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The role and future prospects of artificial intelligence algorithms in peptide drug development

A 2021 review published in Clinical Pharmacology & Therapeutics noted that most therapeutic peptides undergo proteolytic degradation rather than CYP450-mediated metabolism, making formal hepatic impairment studies less common in peptide drug development [4]

But for decades, synthetic peptides have been used in drugs to treat a variety of health conditions, including diabetes, with medications like insulin and GLP-1 drugs such as Ozempic