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Venous overload choroidopathy: a hypothetical framework for central serous chorioretinopathy and allied disorders

Potential Direct Cardiovascular Effects: While the primary mechanisms of cardiovascular benefit are likely mediated through weight loss and metabolic improvements, some preclinical and early clinical data suggest that GLP-1 receptor agonists, and potentially GIP receptor agonists, may have direct effects on the heart and blood vessels, such as reducing inflammation and improving endothelial function

In addition, 89.2% of subjects receiving oral semaglutide (50 mg) lost 5% or more of their body weight at 68 weeks, compared to 24.5% with placebo

In large clinical trials, tirzepatide demonstrated significant total body weight loss over time

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Tighter rules could also result in fewer employees accessing the medication or shifting costs elsewhere in the healthcare plan