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In ischemiareperfusion injury models, it preserved vascular integrity and reduced inflammation in organs such as liver, kidney, and lungslikely via endothelial stabilization through the nitric-oxide system
Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T: Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells
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Hypoglycemia , though uncommon with tirzepatide monotherapy, can cause nighttime awakenings, sweating, and restlessness if blood glucose drops too low during sleep
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